Thyrin 25mcg Tablet 15pcs

✔️ Uses of Thyrin 25mcg Tablet

• Treatment of Hypothyroidism (reduced levels of thyroid hormone)

✔️ How does Thyrin 25mcg Tablet work?

Thyrin 25mcg Tablet works by replacing the thyroid hormone which the thyroid gland fails to produce in sufficient quantity in the body thus treating the symptoms of hypothyroidism.

✔️ Side Effects of Thyrin 25mcg Tablet

• Heat intolerance
• Menstrual irregularities
• Muscle weakness
• Increased appetite
• Weight loss
• Diarrhea
• Irregular heartbeat (palpitations)
• Muscle spasm
• Headache,
• Nervousness
• Irritability
• Sleeplessness
• Tremors
• Skin rash

✔️ Quick Suggestions:

• To ensure the effectiveness of the Thyrin 25mcg Tablet and its proper absorption, it should be taken on an empty stomach, preferably in the morning. Avoid consuming any food, milk, or tea for at least 1 hour before and 2 hours after taking the medication.
• It may take approximately 6 to 8 weeks to experience the full effects of Thyrin 25mcg Tablet. It is important to understand that for most individuals, this medication needs to be taken for a lifetime. Do not discontinue the medication without consulting your doctor.
• If you experience symptoms such as diarrhea, nervousness, irritability, sleep disturbances, shaking hands, or chest pain, inform your doctor. They may need to adjust your dosage accordingly.
• Maintain a gap of at least 4 hours between taking Thyrin 25mcg Tablet and any antacids, calcium or iron supplements, and multivitamins, as these may interfere with the medication's effectiveness. Including iodized table salt in your diet is beneficial, as the thyroid gland requires iodine for hormone production. However, excessive iodine intake should be avoided, as it can lead to hyperthyroidism. Consume iodized salt in moderation.
• Maintain a gap of at least 4 hours between taking Thyrin 25mcg Tablet and any antacids, calcium or iron supplements, and multivitamins, as these may interfere with the medication's effectiveness. Including iodized table salt in your diet is beneficial, as the thyroid gland requires iodine for hormone production. However, excessive iodine intake should be avoided, as it can lead to hyperthyroidism. Consume iodized salt in moderation.
• A well-balanced diet with a variety of vegetables is recommended for individuals with hypothyroidism. Since hypothyroidism can lead to the loss of calcium (hypocalcemia) and vitamin D in the body, it is advisable to include calcium-enriched foods in your diet. Increasing protein intake, such as eggs, milk, and pulses, can help boost metabolism in individuals with slower metabolism due to hypothyroidism.
• Engaging in daily yoga and aerobic exercises can promote relaxation and enhance metabolism. Including more vegetables, fruits, and lean meats in your diet can help prevent weight gain, as these foods are generally low in calories.
• Avoid consuming goitrogens, which are substances that interfere with the normal function of the thyroid gland. Examples of goitrogenic foods include soy foods (tofu), cabbage, broccoli, kale, cauliflower, spinach, cassava, peaches, strawberries, millet, pine nuts, sweet potatoes, and peanuts.
• Regularly monitor your hormone levels and promptly inform your doctor if you notice a significant change in your body weight. Dosage adjustments may be necessary based on these changes. Additionally, it is important to consult your doctor before switching brands of Thyrin 25mcg Tablet, as different brands may have varying effects.

✔️ Indication of Thyrin 25mcg Tablet

• Treats primary, secondary and tertiary congenital or acquired hypothyroidism.
• To manage thyrotropin-dependent well-differentiated papillary or follicular carcinoma of thyroid gland (with adjunct to surgery and radioiodine therapy)

✔️ Pharmacology

Synthetic Levothyroxine, also known as Thyroxine or T4, is a component of Thyrin 25 tablets and is identical to the thyroid hormone T4 found in nature. About 30% of T4 is converted into the much more active triiodothyronine in peripheral tissues (T3). TBG is the main transporter of T4 (Thyroxine Binding Globulin). This binding gives T4 a longer half-life in circulation by shielding it from metabolism and excretion. Only 0.03 percent of the total T4 in plasma is unbound. In the body, T4 has a half-life of 6 to 7 days. In hyperthyroidism, the half-life is 3–4 days, whereas, in hypothyroidism, it can be 9–10 days.      

✔️ Dosage & Administration of Thyrin 25mcg Tablet

Adult dose:

• The initial starting dose of 25–50 meg/day, with dose increases as needed at intervals of 6–8 weeks. Until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH has normalized, the dose of levothyroxine sodium is typically increased by 12.5 to 25 meg.
• Until the TSH level is normalized, patients with severe hypothyroidism should receive an initial dose of 12.5–25 meg/day, followed by increases of 25 meg/day every 2-4 weeks, along with clinical and laboratory evaluation.
• in those with secondary or tertiary (pituitary) (hypothalamic)

Hypothyroidism: 

• The serum free-T4 level should be raised to the upper half of the normal range and the dosage of Levothyroxine Sodium should be increased until the patient is clinically euthyroid.
• 1.7 meg/kg/day for patients who are older than 50 or younger than 50 with an underlying cardiac condition

✔️ Interaction

• Concomitant use of Thyroid hormones with any of the following drugs or substances may lead to the occurrence of clinically relevant interactions:
• Oral anticoagulants: Thyroid hormones may enhance the activity of oral anticoagulants.
• Antidiabetic drugs: Thyroid hormones may cause increases in insulin or oral hypoglycaemic drug requirements.
• Digitalis preparations: Thyroid hormones may alter the requirement for Digitalis preparations.
• Cholestyramine: The absorption of Thyroid hormones may be decreased by Cholestyramine; therefore, there should be an interval of at least 4 hours between administrations.

✔️ Contraindications

Untreated subclinical or overt Thyrotoxicosis of any etiology, Acute Myocardial Infarction, Uncorrected Adrenal failure.

✔️ Pregnancy & Lactation

The administration of Norethisterone during pregnancy is contraindicated. Norethisterone should not be used during lactation.

✔️ Precautions & Warnings

• In patients whose hypothyroidism is brought on by a decline in pituitary gland function, there may be adrenocortical insufficiency; this should be addressed with appropriate corticosteroid replacement before beginning levothyroxine therapy to prevent acute adrenal insufficiency.
• The initial dose and any subsequent dose increases in patients with cardiovascular disease and/or severe and long-term hypothyroidism should be carefully considered.
• A high starting dose or an abrupt increase in dosage, particularly in elderly patients, can cause or worsen angina, arrhythmias, myocardial infarction, cardiac failure, or a rapid rise in blood

✔️ Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.